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The Institute of Medical and Biological Engineering (iMBE) brings together colleagues from the faculties of medicine and health, biological sciences and engineering, Their purpose is to deliver pioneering multidisciplinary research and education in the fields of medical devices and regenerative medicine, underpinned by innovation and translation of novel therapies, focusing on the treatment of orthopaedic and cardiovascular diseases and disabilities, to advance patient healthcare and quality of life. Funded by a range of public and private grants, iMBE is developing replacement tissue products and the next generation of joint replacements which will offer "fifty more years after fifty" and enable each of us to enjoy our longer lives in the best possible health. Joint Action was launched in 2004 to redress the lack of funding for orthopaedic research which currently stands at less than 5% of government research funding, despite the fact that 50% of the UK population will requi